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KMID : 0043320140370010060
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Archives of Pharmacal Research
2014 Volume.37 No. 1 p.60 ~ p.68
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Natural and synthetic biomaterials for controlled drug delivery
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Kim Jang-Kyoung
Kim Hyung-Jin
Chung Jee-Young
Lee Jong-Hwan
Young Seok-Beom
Kim Yong-Hee
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Abstract
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A wide variety of delivery systems have been developed and many products based on the drug delivery technology are commercially available. The development of controlled-release technologies accelerated new dosage form design by altering pharmacokinetic and pharmacodynamics profiles of given drugs, resulting in improved efficacy and safety. Various natural or synthetic polymers have been applied to make matrix, reservoir or implant forms due to the characteristics of polymers, especially ease of control for modifications of biocompatibility, biodegradation, porosity, charge, mechanical strength and hydrophobicity/hydrophilicity. Hydrogel is a hydrophilic, polymeric network capable of imbibing large amount of water and biological fluids. This review article introduces various applications of natural and synthetic polymer-based hydrogels from pharmaceutical, biomedical and bioengineering points of view.
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KEYWORD
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Hydrogel, Drug delivery, Natural polymers, Synthetic polymers, Protein release
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